L. (Linda) Mbeki

Linda MbekiLinda has a background in synthetic organic chemistry. Her MSc project at the University of Cape Town involved the rational design and synthesis of potential anti-malarial and anti-viral agents. The dual drug approach was chosen to counter different steps of the life cycles of the HI virus and the P. falciparum parasite. A novel methodology was developed in the synthesis of the UC-781 part of the anti-viral dual drug. A series of peptide linked M5-Ferroquine agents were also developed at the Université des Sciences et Technologies de Lille. The project was made possible by GOOT funds. Since December 2011 Linda is a PhD candidate at VU University Amsterdam

PhD research: The archaeology of slavery in Cape Town during the Dutch colonial period

Her PhD work is on the archaeology of slavery in Cape Town during the Dutch colonial period. She is performing archaeometric analyses on artifacts at the Slave Lodge Museum in Cape Town to interrogate the extensive Dutch East India Company archives in The Hague and Cape Town. This multi-disciplinary approach has brought together academics from the University of Cape Town, Rutgers University, the University of the Western Cape, and the Vrije Universiteit Amsterdam. The project would not be possible were it not for the corporation of Iziko Museums and the generosity of the South African National Research Foundation and the Oppenheimer Memorial Trust.

Supervisors: Prof. dr. Henk Kars and prof. dr. Karel Davids. Co-supervisors: Robert Shell and Carmel Shrire

E-mail: l.mbeki@vu.nl

Publications

Bioorganic & Medicinal Chemistry, 2009, 17 (23), 8048 Ferroquine antimalarial activities of conjugates with either glutathione or glutathione reductase inhibitors depletors via a hydrolyzable amide linker.

Tetrahedron Letters, 2005, 46 (23), 4023. New methodology for 2-alkylation of 3-furoic acids: application to the synthesis of tethered UC 781/d4T bifunctional HIV reverse-transcriptase inhibitors.